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Inside a globe with an alternate history, an awesome war ultimately comes to an end leaving the earth diseased and polluted. The geneticist Dr. Azuma vies for assist from the government for his neo-cell remedy that he claims can rejuvenate the physique and regenerate humankind. The federal government leaders, guarding their very own deeply entrenched powers, turn down the professor. Driven to finish his get the job done, Dr. Azuma accepts a secret supply from a sinister faction of the impressive military. Following an incident occurs in Dr. Azuma's lab, a race of mutant humans known as the Shinzo Ningen are unleashed upon the globe. Now only the warrior known as Casshern, reincarnated with an invincible physique, stands in between the Shinzo Ningen as well as a globe around the brink of annihilation.